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Diet and proinflammatory cytokine levels in head and neck squamous cell carcinoma
Author(s) -
Arthur Anna E.,
Peterson Karen E.,
Shen Jincheng,
Djuric Zora,
Taylor Jeremy M. G.,
Hebert James R.,
Duffy Sonia A.,
Peterson Lisa A.,
Bellile Emily L.,
Whitfield Joel R.,
Chepeha Douglas B.,
Schipper Matthew J.,
Wolf Gregory T.,
Rozek Laura S.
Publication year - 2014
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.28778
Subject(s) - proinflammatory cytokine , medicine , head and neck squamous cell carcinoma , cytokine , quartile , cancer , tumor necrosis factor alpha , immunology , gastroenterology , head and neck cancer , confidence interval , inflammation
BACKGROUND Proinflammatory cytokine levels may be associated with cancer stage, recurrence, and survival. The objective of this study was to determine whether cytokine levels were associated with dietary patterns and fat‐soluble micronutrients in patients with previously untreated head and neck squamous cell carcinoma (HNSCC). METHODS This was a cross‐sectional study of 160 patients with newly diagnosed HNSCC who completed pretreatment food frequency questionnaires (FFQs) and health surveys. Dietary patterns were derived from FFQs using principal component analysis. Pretreatment serum levels of the proinflammatory cytokines interleukin‐6 (IL‐6), tumor necrosis factor alpha (TNF‐α), and interferon gamma (IFN‐γ) were measured using an enzyme‐linked immunosorbent assay, and serum carotenoid and tocopherol levels were measured by high‐performance liquid chromatography. Multivariable ordinal logistic regression models examined associations between cytokines and quartiles of reported and serum dietary variables. RESULTS Three dietary patterns emerged: whole foods, Western, and convenience foods. In multivariable analyses, higher whole foods pattern scores were significantly associated with lower levels of IL‐6, TNF‐α, and IFN‐γ ( P ≤ .001, P = .008, and P = .03, respectively). Significant inverse associations were reported between IL‐6, TNF‐α, and IFN‐γ levels and quartiles of total reported carotenoid intake ( P = .006, P = .04, and P = .04, respectively). There was an inverse association between IFN‐γ levels and serum α‐tocopherol levels ( P = .03). CONCLUSIONS Consuming a pretreatment diet rich in vegetables, fruit, fish, poultry, and whole grains may be associated with lower proinflammatory cytokine levels in patients with HNSCC. Cancer 2014;120:2704–2712. © 2014 American Cancer Society .