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Stereotactic body radiotherapy: A critical review for nonradiation oncologists
Author(s) -
Kirkpatrick John P.,
Kelsey Christopher R.,
Palta Manisha,
Cabrera Alvin R.,
Salama Joseph K.,
Patel Pretesh,
Perez Bradford A.,
Lee Jason,
Yin FangFang
Publication year - 2013
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.28515
Subject(s) - medicine , radiation therapy , cancer , lung cancer , radiation treatment planning , radiology , medical physics , nuclear medicine , oncology
Stereotactic body radiotherapy (SBRT) involves the treatment of extracranial primary tumors or metastases with a few, high doses of ionizing radiation. In SBRT, tumor kill is maximized and dose to surrounding tissue is minimized, by precise and accurate delivery of multiple radiation beams to the target. This is particularly challenging, because extracranial lesions often move with respiration and are irregular in shape, requiring careful treatment planning and continual management of this motion and patient position during irradiation. This review presents the rationale, process workflow, and technology for the safe and effective administration of SBRT, as well as the indications, outcome, and limitations for this technique in the treatment of lung cancer, liver cancer, and metastatic disease. Cancer 2014;120:942–954 . © 2013 American Cancer Society .