Premium
Mammographic screening interval in relation to tumor characteristics and false‐positive risk by race/ethnicity and age
Author(s) -
O'Meara Ellen S.,
Zhu Weiwei,
Hubbard Rebecca A.,
Braithwaite Dejana,
Kerlikowske Karla,
Dittus Kim L.,
Geller Berta,
Wernli Karen J.,
Miglioretti Diana L.
Publication year - 2013
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.28310
Subject(s) - medicine , race (biology) , ethnic group , interval (graph theory) , demography , oncology , gynecology , botany , mathematics , combinatorics , anthropology , biology , sociology
BACKGROUND Biennial screening mammography retains most of the benefits of annual breast cancer screening with reduced harms. Whether screening guidelines based on race/ethnicity and age would be more effective than age‐based guidelines is unknown. METHODS Mammography data from the Breast Cancer Surveillance Consortium were linked to pathology and tumor databases. The authors identified women aged 40 to 74 years who underwent annual, biennial, or triennial screening mammography between 1994 and 2008. Logistic regression was used to estimate adjusted odds ratios (OR) and 95% confidence intervals (95% CI) of adverse tumor characteristics among 14,396 incident breast cancer cases and 10‐year cumulative risks of false‐positive recall and biopsy recommendation among 1,276,312 noncases. RESULTS No increased risk of adverse tumor characteristics associated with biennial versus annual screening were noted in white women, black women, Hispanic women aged 40 to 49 years, or Asian women aged 50 to 74 years. Hispanic women aged 50 to 74 years who screened biennially versus annually were found to have an increased risk of late‐stage disease (OR, 1.6; 95% CI, 1.0‐2.5) and large tumors (OR, 1.6; 95% CI, 1.1‐2.4). Asian women aged 40 to 49 years who underwent biennial screening had an elevated risk of positive lymph nodes (OR, 3.1; 95% CI, 1.3‐7.1). No elevated risks were associated with triennial versus biennial screening. Cumulative false‐positive risks decreased markedly with a longer screening interval. CONCLUSIONS The authors found limited evidence of elevated risks of adverse tumor characteristics with biennial versus annual screening, whereas cumulative false‐positive risks were lower. However, elevated risks of late‐stage disease in Hispanic women and lymph node‐positive disease in younger Asian women who screened less often than annually warrant consideration and replication. Cancer 2013 ;119:3959–3967. © 2013 American Cancer Society .