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Bone mineral density following surgical oophorectomy and tamoxifen adjuvant therapy for breast cancer
Author(s) -
Love Richard R.,
Young Gregory S.,
Laudico Adriano V.,
Dinh Nguyen,
Uy Gemma B.,
Quang Le Hong,
Peña Arturo S.,
Dofitas Rodney B.,
Bisquera Orlino C.,
Siguan Stephen S. S.,
Salvador Jonathan D. S.,
MirasolLumague Maria Rica,
Navarro Narciso S.,
Linh Nguyen Dieu,
Jarjoura David
Publication year - 2013
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.28302
Subject(s) - medicine , oophorectomy , bone mineral , breast cancer , tamoxifen , femoral neck , surgery , menopause , urology , cancer , osteoporosis , hysterectomy
BACKGROUND In premenopausal women treated for breast cancer, loss of bone mineral density (BMD) follows from menopause induced by chemotherapy or loss of ovarian function biochemically or by surgical oophorectomy. The impact on BMD of surgical oophorectomy plus tamoxifen therapy has not been described. METHODS In 270 Filipino and Vietnamese premenopausal patients participating in a clinical trial assessing the impact of the timing in the menstrual cycle of adjuvant surgical oophorectomy on breast cancer outcomes, BMD was measured at the lumbar spine and femoral neck before this treatment, and at 6, 12, and 24 months after surgical and tamoxifen therapies. RESULTS In women with a pretreatment BMD assessment and at least 1 other subsequent BMD assessment, no significant change in femoral neck BMD was observed over the 2‐year period (−0.006 g/cm 2 , −0.8%, P = .19), whereas in the lumbar spine, BMD fell by 0.045 g/cm 2 (4.7%) in the first 12 months ( P < .0001) and then began to stabilize. CONCLUSIONS Surgically induced menopause with tamoxifen treatment is associated with loss of BMD at a rate that lessens over 2 years in the lumbar spine and no significant change of BMD in the femoral neck. Cancer 2013;119:3746–3752. © 2013 American Cancer Society.