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Hodgkin's disease and non‐hodgkin's lymphoma containing reed‐sternberg‐like giant cells in Taiwan: A clinicopathologic analysis of 50 cases
Author(s) -
Hong RueyLong,
Su IhJen,
Chen YaoChang,
Hsieh HongChong,
Wang ChiuHwa,
Liu ChienHui,
Shen MingChing
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.2820690530
Subject(s) - nodular sclerosis , medicine , lymphoma , incidence (geometry) , gastroenterology , working formulation , histology , pathology , stage (stratigraphy) , b symptoms , lymphocyte , disease , large cell , non hodgkin's lymphoma , hodgkin lymphoma , cancer , adenocarcinoma , biology , paleontology , physics , optics
Hodgkin's disease (HD) is uncommon in Taiwan. In reviewing the clinicopathologic features of 50 cases, the authors found that the diagnosis of HD was complicated with non‐Hodgkin's lymphoma (NHL). Fourteen cases were reclassified as NHL containing Reed‐Sternberg (RS) giant cells, mostly peripheral T‐cell lymphoma (PTL), and 34 cases as classic HD, which included 8 cases of lymphocyte predominance, 10 of nodular sclerosis, 12 of mixed cellularity, and 4 of lymphocyte depletion. For cases of HD, there was a bimodal age‐incidence distribution with peaks at the third and fifth decades; 61.8% manifested Stage B symptoms and 80.6% had Stage III/IV disease. The group of patients with NHL, compared with those with classic HD, was found to be older (mean age, 41.4 years versus 33.1 years; P < 0.05), to have more extranodal disease (35.7% versus 8.8%, P < 0.05), less complete remission rate (25% versus 67.9%, P < 0.05), and shorter median survival (29 months versus 90 months). Most of the NHL patients originally were diagnosed as having atypical or unclassified HD. Thus, the authors conclude that the previous observation of a predominance of mixed cellularity HD in Asian regions may be attributable to the inclusion of PTL, which may mimic HD in histology. Because there is a marked difference in clinical behavior and prognosis, it is important to distinguish between HD and NHL containing RS giant cells in an area with a high incidence of PTL.