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Low incidence of human papillomavirus type 16 DNA in bladder tumor detected by the polymerase chain reaction
Author(s) -
Chetsanga C.,
Malmström P.U.,
Gyllensten U.,
MorenoLopez J.,
Dinter Z.,
Pettersson U.
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.2820690523
Subject(s) - polymerase chain reaction , medicine , human papillomavirus , genital warts , urinary bladder , incidence (geometry) , pathology , carcinoma , nested polymerase chain reaction , sex organ , transitional cell carcinoma , hpv infection , cancer , bladder cancer , biology , cervical cancer , gene , biochemistry , physics , genetics , optics
Human papillomavirus (HPV) detection was done using the polymerase chain reaction technique on tumor tissue from 44 patients with transitional cell carcinoma of the urinary bladder. Only one of the 44 was associated with HPV infection. The HPV‐positive patient was not known to have immunodeficiency or genital warts, and the tumor was not morphologically different from the other tumors. Control experiments excluded the possibility that this finding was caused by contamination of the sample. This study confirms that HPV infection is a. rare condition in bladder carcinoma.