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Primary biphasic lymphoplasmacytic lymphoma of the lung: A mucosa‐associated lymphoid tissue lymphoma with compartmentalization of plasma cells in the lung and lymph nodes
Author(s) -
Chetty R.,
Close P. M.,
Timme A. H.,
Willcox P. A.,
Forder M. D.
Publication year - 1992
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.2820690511
Subject(s) - pathology , lymphatic system , lymph , lymphoma , in situ hybridization , immunoglobulin light chain , medicine , lung , mucosa associated lymphoid tissue , malt lymphoma , biology , immunology , antibody , messenger rna , gene , biochemistry
A primary mucosa‐associated lymphoid tissue lymphoma of the lung in a 27‐year‐old man was found. The tumor was composed mainly of centrocyte‐like cells and plasma cells. These two components were demarcated sharply from each other, resulting in a zoning or biphasic pattern. This characteristic pattern also was present in the involved regional lymph nodes. Monoclonality of tumor cells was shown immunohistochemically and by in situ hybridization techniques. This article also highlights the use of in situ hybridization in detecting light chain mRNA in paraffin sections.