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Lymphographic demonstration of cyclic changes in lymph node size during pel‐epstein fever
Author(s) -
Scanlon Gerard T.,
Castellino Ronald A.,
Rudders Richard
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.2820360916
Subject(s) - medicine , lymph , lymph node , fever of unknown origin , high fever , disease , pathology , surgery
Pel‐Epstein fever cycles, consisting of 1–2 weeks of high fever separated by afebrile periods of the same duration, are classically characteristic of Hodgkin's disease. Clinical observation has determined that the lymph nodes enlarge during periods of fever and reduce in size as the fever subsides. To our knowledge, the waxing and waning of lymph nodes in tempo with the fever cycle in Hodgkin's disease have never before been documented by lymphography. The alterations we verified radiographically resemble cyclic swings in classic autoimmune diseases. Speculations are offered regarding the observed changes.