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“Skip” metastases in osteosarcoma
Author(s) -
Enneking W. F.,
Kagan A.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.2820360637
Subject(s) - medicine , osteosarcoma , sarcoma , natural history , metastasis , pathology , incidence (geometry) , primary tumor , disease , focus (optics) , radiology , cancer , physics , optics
Careful study of 40 cases of osteosarcoma without evidence of multifocal disease, pulmonary metastasis, or history of exposure to predisposing factors has given histologic evidence of microscopic foci of osteosarcoma separate from the primary focus of osteogenic sarcoma. These “skip” lesions are to all pathologic examination completely separate from the primary focus of osteogenic sarcoma. They are more often found proximal to the primary, both intraosseously and transarticularly. Histologically, these “skips” represent areas of osteosarcoma which in many cases are a less‐differentiated form of the tumor. The natural history of such tumors with “skips” following ablative surgery is an increased incidence of local recurrence and subsequent pulmonary metastases.