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Childhood hodgkin's disease in israel: A study of 17 cases
Author(s) -
Aghai E.,
Brenner H.,
Ramot B.
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.2820360630
Subject(s) - medicine , nodular sclerosis , radiation therapy , chlorambucil , vinblastine , stage (stratigraphy) , pediatrics , procarbazine , incidence (geometry) , disease , chemotherapy , surgery , vincristine , lymphoma , cyclophosphamide , hodgkin lymphoma , paleontology , physics , optics , biology
A study of 17 children suffering from Hodgkin's disease (H.D.) is presented. The special ethnic distribution with predominance in Arab and Oriental Jewish children is noted. A high incidence of mixed cellularity histology in Arab children is emphasized. A conservative approach to therapy, i.e. extended field regional radiotherapy only, resulted in a long first complete remission period in lymphocyte predominance and nodular sclerosis H.D. Stages I A and II A. All children in Stage III B and IV were treated by six courses of combined chemotherapy, and were maintained either on chlorambucil and vinblastine or on MOPP. Patients with mixed cellularity H.D. Stage II A and all patients in Stage III A were treated by four courses of MOPP after the completion of extended regional radiotherapy. The 5 children who did not receive the scheduled treatment died. The remaining 12 are well, with a survival of 8 to 104 months.