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Vincristine‐induced myocardial infarction
Author(s) -
Mandel Eugen M.,
Lewinskimd Uri,
Djaldetti Meir
Publication year - 1975
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.2820360608
Subject(s) - vincristine , medicine , myocardial infarction , infarction , in vivo , cardiology , lymphoma , chemotherapy , cyclophosphamide , microbiology and biotechnology , biology
A patient with lymphosarcoma treated with weekly injections of vincristine developed an acute myocardial infarction immediately after the second injection of vincristine. After he recovered from the infarction, the treatment was continued and he developed an additional myocardial infarction. In vivo and in vitro studies have not revealed any effect of vincristine on the clotting mechanism. The possible causes for the association of vincristine‐treated lymphoma and myocardial infarction are discussed. Canceri 36:1979–1982, 01975