Premium
Impact of carbon ion radiotherapy for primary spinal sarcoma
Author(s) -
Matsumoto Keiji,
Imai Reiko,
Kamada Tadashi,
Maruyama Katsuya,
Tsuji Hiroshi,
Tsujii Hirohiko,
Shioyama Yoshiyuki,
Honda Hiroshi,
Isu Kazuo
Publication year - 2013
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.28177
Subject(s) - medicine , sarcoma , radiation therapy , surgery , carbon ion radiotherapy , cohort , spinal cord compression , spinal cord , pathology , psychiatry
BACKGROUND Spinal sarcomas have been one of the most challenging diseases for orthopedic surgeons. The objective of this study was to retrospectively analyze carbon ion radiotherapy (CIRT) treatment results for spinal sarcoma. METHODS Forty‐seven patients with 48 medically unresectable spinal sarcomas, excluding sacral tumors, received treatment with CIRT between 1996 and 2011. All patients were enrolled in phase 1/2 and phase 2 clinical trials of CIRT for bone and soft tissue sarcoma. The applied dose ranged from 52.8 gray equivalents (GyE) to 70.4 GyE (median, 64.0 GyE) in 16 fixed fractions over 4 weeks. RESULTS The median patient age was 54 years, and the cohort included 24 men and 23 women. Thirty‐five patients were without prior treatment, and 12 patients had locally recurrent tumors after previous resection. The median follow‐up was 25 months, and the median survival was 44 months (range, 5.2‐148 months). The 5‐year local control, overall survival, and progression free rates were 79%, 52%, and 48%, respectively. None of the 15 patients who had tumors measuring <100 cm 3 had a local recurrence. No fatal toxicities occurred during follow‐up. One patient each had a grade 3 late skin reaction and a grade 4 late skin reaction. Vertebral body compression was observed in 7 patients. One patient had a grade 3 late spinal cord reaction. Twenty‐two of the surviving 28 patients who had primary tumors remained ambulatory without supportive devices. CONCLUSIONS CIRT appears to be both effective and safe for the treatment of patients with unresectable spinal sarcoma. Cancer 2013;119:3496–3503. . © 2013 American Cancer Society .