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Phase 1 trial of preoperative, short‐course carbon‐ion radiotherapy for patients with resectable pancreatic cancer
Author(s) -
Shinoto Makoto,
Yamada Shigeru,
Yasuda Shigeo,
Imada Hiroshi,
Shioyama Yoshiyuki,
Honda Hiroshi,
Kamada Tadashi,
Tsujii Hirohiko,
Saisho Hiromitsu
Publication year - 2012
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.27723
Subject(s) - medicine , carbon ion radiotherapy , radiation therapy , pancreatic cancer , surgery , cancer , short course , metastasis , pediatrics
BACKGROUND: The authors evaluated the tolerance and efficacy of carbon‐ion radiotherapy (CIRT) as a short‐course, preoperative treatment and determined the recommended dose needed to reduce the risk of postoperative local recurrence without excess injury to normal tissue. METHODS: Patients radiographically defined with potentially resectable pancreatic cancer were eligible. A preoperative, short‐course, dose‐escalation study was performed with fixed 8 fractions in 2 weeks. The dose of irradiation was increased by 5% increments from 30 grays equivalents (GyE) to 36.8 GyE. Surgery was to be performed 2 to 4 weeks after the completion of CIRT. RESULTS: The study enrolled 26 patients. At the time of restaging after CIRT, disease progression with distant metastasis or refusal ruled out 5 patients from surgery. Twenty‐one of 26 patients (81%) patients underwent surgery. The pattern of initial disease progression was distant metastasis in 17 patients (65%) and regional recurrence in 2 patients (8%). No patients experienced local recurrence. The 5‐year survival rates for all 26 patients and for those who underwent surgery were 42% and 52%, respectively. CONCLUSIONS: Preoperative, short‐course CIRT followed by surgery is feasible and tolerable without unacceptable morbidity. Cancer 2013. © 2012 American Cancer Society.