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Clinical significance of gastritis cystica profunda and its association with Epstein‐Barr virus in gastric cancer
Author(s) -
Choi MinGew,
Jeong Ji Yun,
Kim KyoungMee,
Bae Jae Moon,
Noh Jae Hyung,
Sohn Tae Sung,
Kim Sung
Publication year - 2012
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.27541
Subject(s) - medicine , cancer , gastroenterology , lymphovascular invasion , perineural invasion , lymph node , pathology , metastasis
BACKGROUND: Gastritis cystica profunda (GCP) is a relatively rare disorder characterized by hyperplastic and cystic down growth of gastric glands into the submucosa. In the current study, the authors attempted to clarify the clinical and pathologic features of GCP in patients with gastric cancer. METHODS: The records of 10,728 patients with gastric cancer who underwent gastric cancer surgery were reviewed. The clinicopathologic features of patients who had GCP (n = 161) were compared with the features of patients without GCP (n = 10,567). In situ hybridization to determine Epstein‐Barr virus (EBV) positivity was performed in cancer tissues from patients with (n = 119) and without (n = 503) GCP. RESULTS: GCP was associated significantly with older age, male gender, proximal tumor location, differentiated histology and Lauren intestinal type compared with non‐GCP. GCP also was present more frequently in remnant and multiple gastric cancers. Patients who had GCP presented with earlier tumor stages in terms of depth of invasion and lymph node metastasis, and they had less lymphatic and perineural invasion than patients without GCP; however, the presence of GCP was not an independent prognostic factor. The EBV‐positive rate was significantly higher in the GCP group (31.1%) than in the non‐GCP group (5.8%). CONCLUSIONS: Patients with gastric cancer who had GCP had clinicopathologic features that differed from the features observed in patients without GCP. GCP was associated significantly with EBV‐positive gastric cancers, and its possible role as a premalignant lesion needs to be clarified. Cancer 2012. © 2012 American Cancer Society.