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A phase 1 trial of E7974 administered on day 1 of a 21‐day cycle in patients with advanced solid tumors
Author(s) -
RochaLima Caio M.,
Bayraktar Soley,
MacIntyre Jessica,
Raez Luis,
Flores Aurea M.,
Ferrell Annapoorna,
Rubin Eric H.,
Poplin Elizabeth A.,
Tan Antoinette R.,
Lucarelli Antonio,
Zojwalla Naseem
Publication year - 2012
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.27428
Subject(s) - medicine , pharmacokinetics , neutropenia , refractory (planetary science) , toxicity , cohort , febrile neutropenia , gastroenterology , vinca , urology , surgery , pharmacology , physics , astrobiology
BACKGROUND: E7974, a synthetic analog of hemiasterlin, interacts with the tubulin molecule and overcomes resistance to other antitubulin drugs (taxanes and vinca alkaloids). METHODS: In a phase 1 study, E7974 was given intravenously over a 2‐ to 5‐minute infusion on day 1 of every 21‐day cycle. Adult patients with advanced refractory solid tumors who had adequate organ function and Eastern Cooperative Oncology Group performance status 0 to 2 were eligible for this study. A modified Fibonacci schema was used. The maximal tolerated dose (MTD) was the dose where <2 of 6 patients developed a dose‐limiting toxicity (DLT). RESULTS: Twenty‐eight patients (19 men and 9 women; median age, 64 years) treated at different cohort dose levels (0.18 mg/m 2 , 0.27 mg/m 2 , 0.36 mg/m 2 , 0.45 mg/m 2 , and 0.56 mg/m 2 ) received a total of 66 courses of E7974. The MTD was established at 0.45 mg/m 2 , where 1 of 6 patients experienced DLT (grade 4 febrile neutropenia). Of the 17 refractory colon cancer patients with a median of 3 prior treatments, stable disease was seen in 7 patients (41%). There were no tumor responses. Median progression‐free survival was 1.2 months, and median overall survival was 6.7 months. In pharmacokinetic analysis, E7974 was characterized by a fast and moderately large distribution (37.95‐147.93 L), slow clearance (2.23‐7.15 L/h), and moderate to slow elimination (time to half‐life, 10.4‐30.5 hours). CONCLUSIONS: This study shows that E7974 once every 21‐day cycle shows antitumor activity in patients with refractory solid tumors. The recommended phase 2 dose is 0.45 mg/m 2 . Cancer 2012. © 2012 American Cancer Society