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Predicting toxicity from radiation therapy—It's genetic, right?
Author(s) -
Kelsey Chris R.,
Rosenstein Barry S.,
Marks Lawrence B.
Publication year - 2011
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.26670
Subject(s) - medicine , toxicity , candidate gene , single nucleotide polymorphism , bioinformatics , radiation therapy , gene , computational biology , genetics , biology , genotype
Although several single‐nucleotide polymorphisms have been associated with radiation‐induced toxicity in candidate gene studies, there are many important limitations to such analyses. The primary limitations include the approach (candidate gene vs genome wide), small patient numbers, lack of a validation set, and subjective endpoints.