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A phase II study of the survivin suppressant YM155 in patients with refractory diffuse large B‐cell lymphoma
Author(s) -
Cheson Bruce D.,
Bartlett Nancy L.,
Vose Julie M.,
LopezHernandez Andres,
Seiz Amanda L.,
Keating Anne T.,
Shamsili Setareh
Publication year - 2011
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.26510
Subject(s) - medicine , refractory (planetary science) , survivin , diffuse large b cell lymphoma , lymphoma , rituximab , phases of clinical research , toxicity , clinical trial , oncology , gastroenterology , anemia , cancer , surgery , physics , astrobiology
BACKGROUND: Few effective therapeutic options exist for patients with refractory diffuse large B‐cell lymphoma (DLBCL). YM155 is a survivin suppressant with activity against DLBCL in a phase I trial. This phase II study was conducted to better characterize the toxicity and efficacy of this small molecule in patients with refractory DLBCL. METHODS: Forty‐one patients with a median age of 66 years and 3 prior regimens were enrolled and treated with a YM155 dose of 5 mg/m 2 /d by continuous infusion for 168 hours every 21 days for up to 15 cycles of treatment. The median number of completed cycles was 3. RESULTS: One patient had a complete remission (CR) (2.4%) with an additional 2 patients (5.9%) responding, with a median progression‐free survival of 58 days. CONCLUSIONS: YM155 was well tolerated with major toxicities including anemia and fatigue. Whereas YM155 had limited single‐agent activity, preclinical data suggest its role in combination with other agents, including rituximab, and a study of that combination in ongoing. Cancer 2012;118: 3128–34. © 2011 American Cancer Society.