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High‐dose cytarabine induction is well tolerated and active in patients with de novo acute myeloid leukemia older than 60 years
Author(s) -
Arellano Martha,
Winton Elliott,
Pan Lin,
Lima Lisa,
Tighiouart Mourad,
Bhalla Kapil,
Heffner Leonard T.,
Neely Jessica,
Hutcherson Donald,
McLemore Morgan,
Langston Amelia,
Khoury H. Jean
Publication year - 2011
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.26290
Subject(s) - medicine , cytarabine , regimen , tolerability , myeloid leukemia , surgery , gastroenterology , adverse effect
BACKGROUND: High‐dose cytarabine (HiDAC) is safe and very effective in younger patients with acute myeloid leukemia (AML), but it generally is not well tolerated in the elderly. METHODS: The authors explored the safety and tolerability of a modified HiDAC induction regimen consisting of 6 daily doses of cytarabine at 2 g/m 2 in combination with 3 daily doses of daunorubicin at 45 mg/m 2 in 59 consecutive patients aged >60 years who had de novo AML diagnosed between July 1996 and February 2005. RESULTS: The median patient age was 68 years (range, 60‐86 years). The regimen was well tolerated. Infections were common and occurred in 39% of patients, but cerebellar toxicities occurred in only 7% of patients and were reversible. The day‐30 induction‐related mortality rate was 10%. Overall, 69% of patients achieved complete remissions (CR), and 80% received up to 3 consolidations with HiDAC. The median follow‐up for surviving patients was 53 months (range, 17‐114 months). The median overall survival was 15.3 months (range, 1‐114 months), and the relapse‐free survival was 13.8 months (range, 1‐113 months). Survival for patients who achieved CR was 27 months (range, 2‐114 months). CONCLUSIONS: The modified HiDAC regimen was well tolerated in patients aged >60 years with AML and was associated with low induction mortality and high rates of CR. Nevertheless, these high remissions still were associated with poor overall outcomes. Cancer 2011;. © 2011 American Cancer Society.