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Neoadjuvant gemcitabine and cisplatin chemotherapy for locally advanced urothelial cancer of the bladder
Author(s) -
Scosyrev Emil,
Messing Edward M.,
van Wijngaarden Edwin,
Peterson Derick R.,
Sahasrabudhe Deepak,
Golijanin Dragan,
Fisher Susan G.
Publication year - 2011
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.26238
Subject(s) - medicine , cystectomy , gemcitabine , bladder cancer , chemotherapy , stage (stratigraphy) , cisplatin , neoadjuvant therapy , urology , clinical endpoint , oncology , retrospective cohort study , cohort , cancer , clinical trial , paleontology , breast cancer , biology
BACKGROUND: The purpose of this study was to investigate the effect of neoadjuvant chemotherapy with gemcitabine and cisplatin (GC) on pathologic down‐staging of patients with locally advanced urothelial cancer (UC) of the bladder. METHODS: This was a retrospective cohort study of patients treated with radical cystectomy (RC) for clinical stage cT2‐T4, N any, M0 bladder UC at Strong Memorial Hospital from 1999 to 2009. The primary exposure variable was use of neoadjuvant chemotherapy (GC vs none). The primary outcome was stage pT0 at RC. Secondary outcomes included other down‐staging end points in the bladder (