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Does “in situ lymphoma” occur as a distinct step in the development of nodular lymphocyte‐predominant Hodgkin lymphoma?
Author(s) -
Carbone Antonino
Publication year - 2011
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.26228
Subject(s) - lymphoma , germinal center , pathology , in situ , medicine , follicular lymphoma , lymphocyte , lymphatic system , lesion , b cell , immunology , antibody , chemistry , organic chemistry
Abstract The concept of in situ neoplasia, already well acknowledged in epithelial tumors, has now been extended to lymphoid neoplasms. Among germinal center (GC)‐derived lymphomas, a type of “in situ follicular lymphoma (FL)” has been described in which cells that strongly express BCL2 are observed in histologically abnormal follicles. In this commentary, the author suggests that another GC‐derived lymphoma, ie, nodular lymphocyte‐predominant Hodgkin lymphoma with a micronodular pattern in which small GCs or broken‐up GCs are present within nodules, may be regarded as an early lesion limited to GC. Like “in situ FL,” this is likely to be an in situ step that potentially leads to overt lymphoma. Cancer 2012;. © 2011 American Cancer Society.