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Oncofertility and preservation of reproductive capacity in children and young adults
Author(s) -
Wallace W. Hamish B.
Publication year - 2011
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.26045
Subject(s) - fertility preservation , medicine , oncofertility , fertility , infertility , premature ovarian insufficiency , gynecology , ovarian tissue cryopreservation , cancer , premature menopause , radiation therapy , young adult , pregnancy , obstetrics , menopause , population , environmental health , biology , genetics
Abstract With increasing numbers of survivors from cancer at a young age, the issue of fertility preservation has assumed greater importance. This review describes normal ovarian and testicular function and summarizes what is known about the effect of chemotherapy and radiotherapy on the gonads and uterus. All young patients with cancer or leukemia should have their fertility prognosis discussed before the initiation of treatment. Sperm and embryo cryopreservation should be considered standard practice and be widely available for those at significant risk of infertility. For prepubertal girls, ovarian tissue cryopreservation should be considered if the risk of premature menopause is high, but for the prepubertal boy there are no established techniques in current practice. Cancer 2011;117(10 suppl):2301–10. © 2011 American Cancer Society.