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The role of technetium‐99m methoxyisobutyl isonitrile scintigraphy in predicting the therapeutic effect of chemotherapy against nasopharyngeal carcinoma
Author(s) -
Wang Xiao Shen,
Zhang Ying Jian,
Liu Xiao Lan,
Zhou Zheng Rong,
Hu Chao Su,
Eisbruch Avraham
Publication year - 2010
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.25802
Subject(s) - chemotherapy , medicine , nasopharyngeal carcinoma , scintigraphy , induction chemotherapy , progressive disease , technetium , technetium 99m , nuclear medicine , cisplatin , radiation therapy
BACKGROUND: The authors prospectively evaluated the correlation between technetium‐99m methoxyisobutyl isonitrile ( 99m Tc‐MIBI) accumulation in tumors and response to induction chemotherapy in patients with nasopharyngeal carcinoma (NPC). METHODS: Eighty‐six patients with locally advanced NPC underwent single‐photon emission computed tomography 15 minutes after an intravenous injection of 740 megabecquerels (20 mCi) 99m Tc‐MIBI before chemotherapy. The tumor uptake ratio (TUR) was calculated. Two weeks after the second cycle of combined chemotherapy with 5‐fluorouracil (5‐FU) and cisplatin (DDP), the tumor response rate was evaluated. The correlation between 99m Tc‐MIBI accumulation in tumors and response to chemotherapy with 5‐FU/DDP was examined. RESULTS: Positive accumulation of 99m Tc‐MIBI in tumors was observed in 76 patients (88.4%). The tumor response was a complete response (CR) in 8 patients, a partial response (PR) in 68 patients, stable disease (SD) in 9 patients, and progressive disease (PD) in 1 patient. The response rate (CR and PR) to 5‐FU/DDP chemotherapy in patients who had positive 99m Tc‐MIBI accumulation (tumor uptake ratio [TUR] >1.1) was higher than that in patients who had negative 99m Tc‐MIBI accumulation (TUR ≤1.1; 98.7% vs 10%; P < .001). CONCLUSIONS: Patients with negative 99m Tc‐MIBI accumulation were resistant to 5‐FU/DDP chemotherapy. 99m Tc‐MIBI imaging in patients with NPC was capable of predicting tumor response to chemotherapy with 5‐FU/DDP and can help in the selection of patients for induction chemotherapy. Cancer 2011. © 2010 American Cancer Society.