Premium
Diabetes and breast cancer among women with BRCA1 and BRCA2 mutations
Author(s) -
Bordeleau Louise,
Lipscombe Lorraine,
Lubinski Jan,
Ghadirian Parviz,
Foulkes William D.,
Neuhausen Susan,
Ainsworth Peter,
Pollak Michael,
Sun Ping,
Narod Steven A.
Publication year - 2010
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.25595
Subject(s) - medicine , breast cancer , hyperinsulinemia , odds ratio , cancer , diabetes mellitus , body mass index , oncology , gynecology , hazard ratio , brca mutation , obstetrics , confidence interval , obesity , endocrinology , insulin resistance
BACKGROUND: Hyperinsulinemia and the metabolic syndrome are both risk factors for breast cancer. It is not clear if diabetes is associated with the risk of breast cancer in women with a BRCA1 or BRCA2 mutation. METHODS: The authors reviewed the medical histories of 6052 women with a BRCA1 or BRCA2 mutation, half of whom had been diagnosed with breast cancer. They estimated the odds ratio for breast cancer, given a self‐report of diabetes. They then estimated the hazard ratio for a new diagnosis of diabetes associated with a history of breast cancer. RESULTS: There was no excess of diabetes in the period before the diagnosis of breast cancer, compared with controls with no diagnosis of breast cancer. The risk of diabetes was doubled among BRCA carriers in the 15‐year period after the diagnosis of breast cancer (relative risk, 2.0; 95% confidence interval [CI], 1.4‐2.8; P = .0001), compared with carriers without cancer. The risk was particularly high for women with a body mass index (BMI) >25.0 kg/m 2 (odds ratio, 5.8; 95% CI, 4.0‐8.6; P = .0001). CONCLUSIONS: After a diagnosis of breast cancer, women with a BRCA1 or BRCA2 mutation face a 2‐fold increase in the risk of diabetes, which is exacerbated by a high BMI. Cancer 2011. © 2010 American Cancer Society.