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Limited resection followed by intraoperative seed implantation is comparable to stereotactic body radiotherapy for solitary lung cancer
Author(s) -
Parashar Bhupesh,
Patel Priti,
Monni Stefano,
Singh Prabhsimranjot,
Sood Nikki,
Trichter Samuel,
Sabbas Albert,
Wernicke A. Gabriella,
Nori Dattatreyudu,
Chao K. S. Clifford
Publication year - 2010
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.25441
Subject(s) - medicine , lung cancer , univariate analysis , brachytherapy , wedge resection , pneumonectomy , retrospective cohort study , lung , surgery , radiation therapy , radiology , statistical significance , resection , multivariate analysis , oncology
BACKGROUND: The objective of this study was to compare the outcomes of patients who underwent wedge resection plus intraoperative brachytherapy versus patients who received stereotactic body radiotherapy (SBRT) for single malignant lung nodules. METHODS: A retrospective chart review included 55 patients who were treated for single lung nodules, and 47 of those patients who had adequate information were chosen for the current analysis. Twenty‐five patients with single malignant lung nodules received SBRT. Twenty‐two patients underwent limited surgical resection plus radioactive seed implantation for solitary malignant lung nodules. RESULTS: Univariate statistical analysis demonstrated a significance difference only for age in the 2 groups: The mean age in the radioactive seed group (66.6 years) was statistically significantly different from the mean of the age in the SBRT group (75.9 years; 2‐sided P = .04). No significant differences were observed between the 2 groups in terms of local control, distant metastasis, survival, or toxicity. CONCLUSIONS: The current results demonstrated comparable efficacy in outcome and toxicity between surgical resection with radioactive seed implantation and SBRT for the treatment of single malignant lung nodules in patients who were not candidates for lobectomy/pneumonectomy. Cancer 2010. © 2010 American Cancer Society.