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Treatment recommendations for primary extradural meningiomas
Author(s) -
Mattox Austin,
Hughes Betsy,
Oleson James,
Reardon David,
McLendon Roger,
Adamson Cory
Publication year - 2010
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.25384
Subject(s) - medicine , meningioma , resection , adjuvant therapy , primary treatment , radiology , surgery , general surgery , chemotherapy
Primary extradural meningiomas (PEMs) represent about 2% of all meningiomas and are often encountered by non‐neurosurgeons. These lesions typically present as enlarging, painless, benign masses that can be surgically cured. Imaging is critical for defining involvement of adjacent structures; however, diagnosis depends on classic histologic patterns. Treatment for benign PEMs (WHO I) consists of resection with wide margins, whereas adjuvant therapy after resection of atypical (WHO II) or malignant (WHO III) PEMs should be considered. By using the collective experience from our comprehensive cancer center, including neuro‐oncologists, neuroradiologists, and neurosurgeons, in addition to a complete literature review, the authors have established treatment guidelines not previously reported. This manuscript describes key features of these challenging tumors to aid in diagnosis, presents the largest published review of all reported PEMs (n = 163), and provides salient treatment guidelines to surgeons unfamiliar with these challenging tumors. Cancer 2011. © 2010 American Cancer Society.