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Angiogenesis and vascular targeting in Ewing sarcoma
Author(s) -
DuBois Steven G.,
Marieyssa,
GladeBender Julia
Publication year - 2009
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.24844
Subject(s) - medicine , sarcoma , angiogenesis , cancer , ewing's sarcoma , cancer research , bone cancer , bone sarcoma , blood cancer , oncology , pathology , osteosarcoma
Ewing sarcoma is the second most common type of bone cancer in children and young adults. In recent years, the mechanisms by which these tumors develop and maintain their vascular supply have been elucidated. Additional work has demonstrated that inhibition of angiogenic pathways or disruption of established vasculature can attenuate the growth of Ewing sarcoma mouse xenografts. Early clinical data suggest that these results also may extend to patients with Ewing sarcoma who are treated with antiangiogenic or antivascular therapies. For the current review, the authors summarized the available data supporting this approach. Cancer 2010. © 2009 American Cancer Society.