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Quality of life after adjuvant intra‐arterial chemotherapy and radiotherapy versus surgery alone in resectable pancreatic and periampullary cancer
Author(s) -
Morak Marjolein J. M.,
Pek Chulja J.,
Kompanje Erwin J. O.,
Hop Wim C. J.,
Kazemier Geert,
van Eijck Casper H. J.
Publication year - 2009
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.24809
Subject(s) - medicine , periampullary cancer , pancreatic cancer , nausea , quality of life (healthcare) , adjuvant , vomiting , randomization , radiation therapy , chemotherapy , cancer , randomized controlled trial , oncology , surgery , gastroenterology , nursing
BACKGROUND: Adjuvant therapies for pancreatic and periampullary cancer reportedly achieve only a marginal survival benefit. In this randomized controlled trial, 120 patients with resected pancreatic or periampullary cancer received either adjuvant celiac axis infusion chemotherapy combined with radiotherapy (CAI/RT) or no adjuvant treatment. The objective of the study was to compare the quality of life (QoL) in patients who received CAI/RT after pancreatoduodenectomy with the QoL in patients who did not receive adjuvant treatment. METHODS: During and after CAI/RT, QoL was assessed using the European Organization for Research and Treatment of Cancer QoL Questionnaire C30 every 3 months during the first 24 months after randomization. RESULTS: Eighty‐six percent of patients (n = 103) completed 1 or more questionnaires. In total, 355 questionnaires were completed. The results indicated that CAI/RT did not impair physical, emotional, or social functioning. During and after CAI/RT, patients had significantly less pain ( P = .02) and less nausea and vomiting ( P = .01). Overall QoL (global functioning) tended to be better ( P = .08) after CAI/RT. CONCLUSIONS: Over a period of 24 months, CAI/RT improved QoL compared with observation alone in patients with resected pancreatic and periampullary cancer. This beneficial effect of CAI/RT was most prominent in the latter half of the follow‐up. Cancer 2010. © 2010 American Cancer Society.