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Cervical cancer histology and tumor differentiation affect 18 F‐fluorodeoxyglucose uptake
Author(s) -
Kidd Elizabeth A.,
Spencer Christopher R.,
Huettner Phyllis C.,
Siegel Barry A.,
Dehdashti Farrokh,
Rader Janet S.,
Grigsby Perry W.
Publication year - 2009
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.24400
Subject(s) - medicine , standardized uptake value , histology , cervical cancer , adenocarcinoma , fluorodeoxyglucose , adenosquamous carcinoma , nuclear medicine , cancer , positron emission tomography , stage (stratigraphy) , population , pathology , biology , paleontology , environmental health
BACKGROUND: This study aimed to evaluate the variation in cervical cancer glucose metabolism for different tumor histologies and levels of differentiation, as measured by the uptake of 18 F‐fluorodeoxyglucose (FDG) by positron emission tomography (PET). METHODS: The study population consisted of 240 patients with International Federation of Gynecology and Obstetrics stages Ib1 through IVb cervical cancer, who underwent a pretreatment FDG‐PET. Tumor histology included 221 squamous cell (SC), 4 adenosquamous (AS), and 15 adenocarcinoma (AC) tumors. There were 14 well, 145 moderately, and 81 poorly differentiated tumors. The stage distribution was as follows: 70 stage I tumors (9 AC, 2 AS, and 59 SC), 102 stage II tumors (3 AC, 1 AS, and 98 SC), 64 stage III tumors (3 AC, 1 AS, and 60 SC), and 4 stage IV tumors (4 SC). From the FDG‐PET, maximal standardized uptake value (SUV max ) was determined. The variation in SUV max was analyzed for differences based on tumor histology and differentiation. RESULTS: For all patients, the mean SUV max was 11.62 (range, 2.50‐50.39). The mean SUV max by histology was as follows: SC, 11.91 (range, 2.50‐50.39); AS, 8.85 (range, 6.53‐11.26); and AC, 8.05 (range, 2.83‐13.92). Squamous versus nonsquamous tumors demonstrated a significant difference in SUV max ( P = .0153). SUV max and tumor volume were not found to be correlated ( R 2 = 0.013). The mean SUV max was 8.58 for well‐differentiated, 11.56 for moderately differentiated, and 12.23 for poorly differentiated tumors. The mean SUV max was significantly different for well‒differentiated versus poorly differentiated cervical tumors ( P = .0474). CONCLUSIONS: Cervical tumor FDG uptake varied by histology and differentiation. SC tumors demonstrated a significantly higher SUV max compared with nonsquamous cell tumors, and poorly differentiated tumors also had a higher SUV max . Cancer 2009. © 2009 American Cancer Society.