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Gemcitabine‐based doublets versus single‐agent therapy for elderly patients with advanced nonsmall cell lung cancer
Author(s) -
Russo Antonio,
Rizzo Sergio,
Fulfaro Fabio,
Adamo Vincenzo,
Santini Daniele,
Vincenzi Bruno,
Gebbia Nicola,
Carreca Ignazio
Publication year - 2009
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.24207
Subject(s) - medicine , tolerability , vinorelbine , gemcitabine , docetaxel , confidence interval , lung cancer , oncology , hazard ratio , odds ratio , discontinuation , carboplatin , chemotherapy , randomized controlled trial , adverse effect , cisplatin
BACKGROUND: Although platinum‐based combinations are considered the best option of care for patients with advanced nonsmall cell lung cancer (NSCLC), single‐agent therapy is the preferred treatment for older patients. Since the late 1990s, various combinations of third‐generation agents (gemcitabine [G], vinorelbine, docetaxel, and paclitaxel) have been tested, yielding contradictory results. The authors of this report performed a literature‐based meta‐analysis to assess the efficacy and tolerability of G‐based doublets compared with single‐agent chemotherapy for elderly patients with NSCLC. METHODS: Data from all published, randomized, phase 3 trials that compared a G‐based doublet with a third‐generation single agent in elderly patients were collected from electronic databases (Medline and the Cochrane Central Register of Controlled Trials), relevant reference lists, and abstract books. Pooled odds ratios (ORs) were calculated for the 1‐year survival rate, the overall response rate (ORR), and grade 3 and 4 toxicities. RESULTS: Four eligible trials (1436 patients) were selected from 442 studies that initially were identified. A significant difference in ORR favoring G‐based doublets over single agents was observed (OR, 0.65; 95% confidence interval [95% CI], 0.51‐0.82 [ P < .001]), whereas the trend toward an improved 1‐year survival rate was not significant (OR, 0.78; 95% CI, 0.57‐1.06 [ P = .169]). Grade 3 and 4 toxicities did not differ significantly except for thrombocytopenia (OR, 1.76; 95% CI, 1.12‐2.76 [ P = .014]). CONCLUSIONS: G‐based doublets appeared to be effective and feasible compared with single agents in the treatment of elderly patients with advanced NSCLC who were not suitable for full‐dose, platinum‐based chemotherapy. Further prospective, elderly specific, phase 3 trials will be necessary. Cancer 2009. © 2009 American Cancer Society.