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Low‐dose azacitidine after allogeneic stem cell transplantation for acute leukemia
Author(s) -
Jabbour Elias,
Giralt Sergio,
Kantarjian Hagop,
GarciaManero Guillermo,
Jagasia Madan,
Kebriaei Partow,
de Padua Leandro,
Shpall Elizabeth J.,
Champlin Richard,
de Lima Marcos
Publication year - 2009
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.24198
Subject(s) - azacitidine , medicine , transplantation , leukemia , hematopoietic stem cell transplantation , exacerbation , surgery , disease , gastroenterology , oncology , gene expression , chemistry , biochemistry , dna methylation , gene
Abstract BACKGROUND: The authors hypothesized that low doses of the hypomethylating agent 5‐azacitidine may maximize the graft‐versus‐leukemia effect and may be tolerated well after allogeneic transplantation (HSCT). METHODS: The drug was given to 17 patients with acute leukemia as salvage for disease recurrence after HSCT (n = 9 patients) or as maintenance therapy (n = 8 patients). 5‐Azacitidine was given subcutaneously daily for 5 days and was repeated every 4 weeks at doses of 16 mg/m 2 (n = 4 patients), 24 mg/m 2 (n = 9 patients), and 40 mg/m 2 (n = 4 patients). A median of 8 cycles was delivered. The median follow‐up was 16 months and 11 months after HSCT and 5‐azacitidine treatment, respectively. RESULTS: Five of 9 patients with recurrent disease responded. Four of 13 responding patients developed disease recurrence while they were receiving 5‐azacitidine after a median of 10 months. The actuarial 1‐year event‐free and overall survival rates were 55% and 90%, respectively. There were no extramedullary toxicities, and no graft‐versus‐host disease exacerbation was observed. CONCLUSIONS: Low‐dose 5‐azacitidine may induce durable remissions for patients who develop disease recurrence after HSCT. Further follow‐up and a larger group of patients will be necessary to confirm these observations. Cancer 2009. © 2009 American Cancer Society.