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Iron supplementation and erythropoiesis‐stimulatory agents in the treatment of cancer anemia
Author(s) -
Pedrazzoli Paolo,
Rosti Giovanni,
Secondino Simona,
Siena Salvatore
Publication year - 2009
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.24115
Subject(s) - medicine , erythropoiesis , anemia , cancer , hepcidin , iron deficiency , chemotherapy , disease , kidney disease , iron supplementation , ineffective erythropoiesis , oncology
Unresponsiveness to erythropoiesis‐stimulatory agents (ESA), which occurs in 30% to 50% of patients, is a major limitation to the treatment of chemotherapy‐related anemia (CRA). This may be related in part to the dysregulation of iron metabolism, leading to functional iron deficiency. However, the use of iron supplementation during treatment with ESA has not been pursued as rigorously in anemic patients with cancer as it has in patients with chronic kidney disease. In this article, the authors discuss the role of iron supplementation in the setting of CRA in view of recent reports that have addressed this issue. Cancer 2009. © 2009 American Cancer Society.