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Primary central nervous system lymphoma
Author(s) -
Kiewe Philipp,
Fischer Lars,
Martus Peter,
Thiel Eckhard,
Korfel Agnieszka
Publication year - 2008
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.23377
Subject(s) - medicine , primary central nervous system lymphoma , chemotherapy , surgery , methotrexate , single center , lymphoma , performance status , cancer , retrospective cohort study , progression free survival
BACKGROUND. This retrospective, single‐center study assessed the feasibility, outcome, and late side effects of the treatment of immunocompetent patients with primary central nervous system lymphoma (PCNSL) at the authors' institution. METHODS. All 72 consecutive patients diagnosed with PCNSL between January 1994 and February 2005 were scheduled to receive high‐dose methotrexate (HDMTX)‐based chemotherapy. RESULTS. The median age of the patients was 62 years and the median Karnofsky performance score (KPS) was 70. Twelve patients did not receive HDMTX‐based chemotherapy because of poor physical condition or renal insufficiency. Of the 60 patients treated with HDMTX‐based chemotherapy, the treatment of 9 was followed with whole‐brain irradiation. Of 54 patients who were evaluable for response, 35 (65%) responded (52% with a complete response and 13% with a partial response), and 19 patients (35%) did not. At a median follow‐up of 58.7 months, the median progression‐free survival was 9 months and the median overall survival (OAS) was 41.4 months. According to the Memorial Sloan‐Kettering Cancer Center (MSKCC) prognosis score, patients could be divided into 3 groups with significantly different OAS: 52.9 months for patients aged <50 years, 42.4 months for patients aged ≥50 years and with a KPS >70, and 5.2 months for patients aged ≥50 years and with a KPS <70 ( P = .009, log‐rank test). CONCLUSIONS. Promising long‐term results could be achieved with HDMTX‐based chemotherapy in patients with PCNSL in this monocenter study. The MSKCC score proved useful for predicting survival. Cancer 2008; 112:1812–20. © 2008 American Cancer Society.