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Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone‐refractory prostate cancer
Author(s) -
Uzzo Robert G.,
Haas Naomi B.,
Crispen Paul L.,
Kolenko Vladimir M.
Publication year - 2008
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.23318
Subject(s) - medicine , prostate cancer , apoptosis , refractory (planetary science) , cancer , prostate , hormone , oncology , treatment modality , cancer research , bioinformatics , biology , biochemistry , astrobiology
New therapeutic strategies are needed to improve treatment outcomes in men with hormone‐refractory prostate cancer. A better understanding of the molecular mechanisms of cell death in response to therapeutic strategies will help avoid ineffective treatment regimens and provide a molecular basis for new therapeutic modalities targeting apoptosis‐resistant forms of prostate cancer. In this review, the authors focused on the established aberrations of apoptosis in hormone‐refractory prostate cancer, and they have described novel treatment strategies to overcome apoptosis resistance. Cancer 2008. © 2008 American Cancer Society.