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Cytogenetic and molecular responses and outcome in chronic myelogenous leukemia
Author(s) -
Kantarjian Hagop,
O'Brien Susan,
Shan Jianqin,
Huang Xuelin,
GarciaManero Guillermo,
Faderl Stefan,
RavandiKashani Farhad,
Verstovsek Srdan,
Beth Rios Mary,
Cortes Jorge
Publication year - 2008
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.23238
Subject(s) - cumulative incidence , imatinib , medicine , chronic myelogenous leukemia , imatinib mesylate , philadelphia chromosome , incidence (geometry) , myeloid leukemia , oncology , leukemia , cohort , biology , chromosomal translocation , genetics , physics , optics , gene
BACKGROUND. Response rates in chronic myeloid leukemia (CML) are now reported based on the cumulative incidence of a single‐time best response. The study aim was to examine the significance of different response criteria for CML on imatinib therapy. METHODS. In all, 276 patients with chronic phase CML on imatinib therapy were analyzed. Cytogenetic and molecular responses were coded as to single best response and response at specific intervals of treatment. RESULTS. The cumulative incidence of complete cytogenetic response (CGCR) with imatinib was 91%; however, the incidence of CGCR at 48 months into therapy was only 78%. Similarly, the incidence of major molecular responses (best cumulative vs landmark at 48 months) were 74% versus 62%, and of undetectable BCR‐ABL transcripts 38% versus 24%. There was a strong association between achievement of major cytogenetic response (Philadelphia chromosome [Ph]‐positivity ≤35%) at 6 months to 12 months and survival as well as progression‐free survival (PFS). Achievement of major molecular response (vs lesser molecular response) in patients in complete cytogenetic response was not associated with significant differences in survival, but showed some association with PFS. Durable CGCR and major molecular responses (documented continuously for ≥12 months) were associated with longer PFS duration but not with survival duration differences. Of interest, major molecular responses documented at least twice were noted in 71% of patients on imatinib therapy; undetectable BCR‐ABL transcripts documented at least twice were noted in 34%. CONCLUSIONS. Achievement and durability of CGCR and of major and complete molecular responses at landmark times predict outcome in CML, and may help in comparing the efficacy of different treatments. Cancer 2008. © 2007 American Cancer Society.