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Race, biochemical disease recurrence, and prostate–specific antigen doubling time in the SEARCH database
Author(s) -
Powell Isaac
Publication year - 2007
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.23045
Subject(s) - medicine , prostate cancer , prostate specific antigen , race (biology) , disease , oncology , population , chromosome , cancer , prostate , doubling time , gynecology , gene , genetics , biology , cell , botany , environmental health
In their study in the current issue of Cancer , Hamilton et al. attempt to resolve conflicting data regarding prostate cancer and racial outcomes. The most interesting findings include a significantly younger population of black men with higher prostate–specific antigen levels, similar tumor grade, and less extracapsular extension, yet with a higher rate of biochemical disease recurrence compared with white men. Recent genetic studies have reported that variants on chromosome 8q24 and CYP3A4 on chromosome 7 are associated with aggressive prostate cancer in young black men.