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The usefulness of 18 F‐fluorodeoxyglucose positron emission tomography ( 18 F‐FDG‐PET) and a comparison of 18 F‐FDG‐pet with 67 gallium scintigraphy in the evaluation of lymphoma
Author(s) -
Tsukamoto Norifumi,
Kojima Masaru,
Hasegawa Masatoshi,
Oriuchi Noboru,
Matsushima Takafumi,
Yokohama Akihiko,
Saitoh Takayuki,
Handa Hiroshi,
Endo Keigo,
Murakami Hirokazu
Publication year - 2007
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.22807
Subject(s) - medicine , lymphoma , positron emission tomography , nuclear medicine , follicular lymphoma , fluorodeoxyglucose , mantle cell lymphoma , pathology , radiology
BACKGROUND. Although studies comparing conventional imaging modalities with 18 F‐fluorodeoxyglucose positron emission tomography ( 18 F‐FDG‐PET) for the detection of lymphoma and although the relations between 18 F‐FDG‐PET and histologic types were reported previously, most studies were not systematic and involved relatively small numbers of patients. METHODS. Two hundred fifty‐five patients with lymphoma had their disease staged using 18 F‐FDG‐PET, and 191 of those patients also were assessed using gallium‐67 scintigraphy ( 67 Ga). Disease sites were identified on a site‐by‐site basis using computed tomography scans and/or magnetic resonance imaging. The results of these conventional imaging modalities were compared with the results from 8 F‐FDG‐PET and 67 Ga, and correlations between the imaging results and pathologic diagnoses were evaluated by using the World Health Organization classification system. RESULTS. Of 913 disease sites in 255 patients, 18 F‐FDG‐PET identified >97% of disease sites of Hodgkin lymphoma (HL) and aggressive and highly aggressive non‐Hodgkin lymphoma. For indolent lymphoma, the detection rate of 18 F‐FDG‐PET was 91% for follicular lymphoma (FL); 82% for extranodal marginal zone B‐cell lymphoma of mucosa‐associated lymphoid tissue, irrespective of plasmacytic differentiation; and approximately 50% for small lymphocytic lymphoma (SLL) and splenic marginal zone lymphoma (SMZL). The results from 67 Ga were similar to those from 18 F‐FDG‐PET for most histologic subtypes. However, the sensitivity of 67 Ga was unexpectedly poor for FL, for mantle cell lymphoma (MCL), and for the nasal type of natural killer/T‐cell lymphoma (NK/T‐nasal), ranging from 30% to 38%. CONCLUSIONS. 18 F‐FDG‐PET was useful for all histologic subtypes of lymphoma other than SLL and SMZL. Compared with 67 Ga, the authors strongly recommend the use of 18 F‐FDG‐PET in patients with FL, MCL, and NK‐nasal. Cancer 2007. © 2007 American Cancer Society.