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Expression patterns of the ATM gene in mammary tissues and their associations with breast cancer survival
Author(s) -
Ye Chuanzhong,
Cai Qiuyin,
Dai Qi,
Shu Xiaoou,
Shin Aesun,
Gao YuTang,
Zheng Wei
Publication year - 2007
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.22592
Subject(s) - breast cancer , medicine , cancer , gene expression , hazard ratio , oncology , proportional hazards model , real time polymerase chain reaction , survival analysis , cancer research , gene , confidence interval , pathology , biology , genetics
BACKGROUND. The ataxia‐telangiectasia mutated ( ATM ) gene plays a critical role in cell‐cycle arrest, apoptosis, and DNA repair. However, to date, no study has directly investigated the association between ATM gene expression and breast cancer survival. METHODS. ATM gene expression levels were evaluated in tumor and adjacent normal tissue from patients diagnosed with primary breast cancer or BBD using quantitative real‐time reverse transcription polymerase chain reaction (RT‐PCR) assays. Cox regression models were used to evaluate the association of ATM gene expression and survival in a cohort of 471 breast cancer patients. RESULTS. In breast cancer cases, ATM expression in cancer tissues was decreased by approximately 50% compared with adjacent normal tissues from the same patients. In BBD cases, the expression level of the ATM gene was similar in benign tumor tissue and adjacent normal tissues. No apparent difference was found in ATM gene expression levels in adjacent normal tissues obtained from cancer patients or BBD controls. Compared with patients with the lowest tertile of the ATM mRNA, patients in the upper 2 tertiles had more favorable disease‐free survival (hazard ratio [HR] = 0.46, 95% confidence interval [CI]: 0.30–0.73 and HR = 0.52, 95% CI: 0.33–0.81, respectively) and overall survival (HR = 0.56, 95% CI: 0.35–0.92 and HR = 0.70, 95% CI: 0.43–1.13, respectively). CONCLUSIONS. The ATM gene expression was down‐regulated in breast cancer tissues and a high ATM gene expression level in breast cancer tissue was associated with a favorable prognosis. Cancer 2007. © 2007 American Cancer Society.