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Comorbidity is an independent predictor of complete remission in elderly patients receiving induction chemotherapy for acute myeloid leukemia
Author(s) -
Etienne Anne,
Esterni Benjamin,
Charbonnier Aude,
Mozziconacci MarieJoëlle,
Arnoulet Christine,
Coso Diane,
Puig Brigitte,
Gastaut JeanAlbert,
Maraninchi Dominique,
Vey Norbert
Publication year - 2007
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.22537
Subject(s) - medicine , myeloid leukemia , comorbidity , induction chemotherapy , multivariate analysis , chemotherapy , charlson comorbidity index , population , retrospective cohort study , leukocytosis , oncology , gastroenterology , environmental health
BACKGROUND. Elderly patients with acute myeloid leukemia (AML) have a poor prognosis, which is explained by the disease itself and by host‐related factors. The objective of this study was to determine the prognostic role of comorbidities in this population. METHODS. For this single‐center, retrospective study, the authors analyzed the outcome of 133 patients aged ≥70 years who received induction chemotherapy for nonpromyelocytic AML between 1995 and 2004. Comorbidities were evaluated by using an adapted form of the Charlson comorbidity index (CCI). RESULTS. The median patient age was 73 years. The CCI score was 0 for 83 patients (68%), 1 for 16 patients (13%), and >1 for 23 patients (19%). The complete remission (CR) rate was 56%, and the median overall survival was 9 months. In multivariate analysis, 4 adverse prognostic factors for CR were identified: unfavorable karyotype, leukocytosis ≥30 g/L, CD34 expression on leukemic cells, and CCI >1. A score could be generated to allow the stratification of patients into low‐, intermediate‐, and high‐risk groups with CR rates of 87%, 63%, and 37%, respectively. The risk of early mortality and the probability of survival also were different in the 3 risk groups ( P = .02 and P = .01, respectively). CONCLUSIONS. The results from this study indicated that associated comorbidities are independent factors that may influence achievement of CR in elderly patients with AML. Such a scoring system may be useful in the prognostic staging systems that are used to identify patients with AML who can benefit from induction chemotherapy. Cancer 2007. © 2007 American Cancer Society.