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Comparison of peripheral T‐cell lymphomas and diffuse large B‐cell lymphoma
Author(s) -
Tomita Naoto,
Motomura Shigeki,
Hyo Rie,
Takasaki Hirotaka,
Takemura Sachiya,
Taguchi Jun,
Fujisawa Shin,
Ogawa Koji,
Ishigatsubo Yoshiaki,
Takeuchi Kengo
Publication year - 2007
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.22507
Subject(s) - medicine , lymphoma , diffuse large b cell lymphoma , international prognostic index , b symptoms , angioimmunoblastic t cell lymphoma , immunophenotyping , oncology , rituximab , peripheral t cell lymphoma , gastroenterology , pathology , t cell , immunology , immune system , flow cytometry
BACKGROUND Peripheral T‐cell lymphomas (PTCLs) are a biologically heterogeneous subgroup of lymphomas with poor prognosis. In this study, the authors analyzed the clinical behaviors of PTCLs and diffuse large B‐cell lymphoma (DLBCL). METHODS The authors compared the characteristics and outcomes of 59 patients with PTCLs, including 33 angioimmunoblastic T‐cell lymphomas and 26 unspecified peripheral T‐cell lymphomas, with the characteristics and outcomes of 193 patients with DLBCLs who were treated in the era before rituximab. RESULTS Based on the clinical characteristics, elevated lactate dehydrogenase (LDH), poor PS, advanced stage, higher International Prognostic Index score, and B symptoms were more common in patients with PTCLs, and bulky mass was more common in patients with DLBCL. The rates of complete response (CR) or an unconfirmed CR (CRu) were higher in patients with DLBCL (72%) than in patients with PTCLs (56%; P = .03). The 5‐year overall survival (OS), progression‐free survival (PFS), and disease‐free survival (DFS) rates were 31%, 26%, and 47%, respectively, in patients with PTCLs and 59%, 55%, and 73%, respectively, in patients with DLBCL ( P = .001, P < .001, and P = .003, respectively). Although multivariate analysis identified several risk factors that were significant in PTCLs, but not in DLBCLs, for the CR/CRu, OS, PFS, and DFS rates, the immunophenotype was not identified as a risk factor. CONCLUSIONS The poor response and survival of patients who had PTCLs, compared with patients who had DLBCL, was caused by numerous initial risk factors. T‐cell phenotype itself did not appear to have a significant impact on either response or survival. Cancer 2007 © 2007 American Cancer Society.