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Lanreotide autogel every 6 weeks compared with Lanreotide microparticles every 3 weeks in patients with well differentiated neuroendocrine tumors
Author(s) -
Bajetta Emilio,
Procopio Giuseppe,
Catena Laura,
Martinetti Antonia,
De Dosso Sara,
Ricci Sergio,
Lecchi Alberto S.,
Boscani Paolo F.,
Iacobelli Stefano,
Carteni Giacomo,
De Braud Filippo,
Loli Paola,
Tartaglia Andreas,
Bajetta Roberto,
Ferrari Leonardo
Publication year - 2006
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.22272
Subject(s) - medicine , lanreotide , dosing , gastroenterology , malignancy , neuroendocrine tumors , response evaluation criteria in solid tumors , surgery , chemotherapy , urology , phases of clinical research , growth hormone , hormone , acromegaly
BACKGROUND. The noninferiority of a 6‐week dosing schedule of lanreotide Autogel (Lan ATG) at a dose of 120 mg compared with a 3‐week dosing schedule of lanreotide microparticles (Lan MP) at a dose of 60 mg was investigated in patients with neuroendocrine tumors (NET). METHODS. Patients who had sporadic, well differentiated NET with a low grade of malignancy were recruited for this open‐label, Phase III, multicenter trial. Patients were randomized to receive either 3 deep subcutaneous injections of Lan ATG (120 mg, every 6 weeks) or 6 intramuscular injections of Lan MP (60 mg, every 3 weeks). Tumor markers, tumor size, and symptoms were assessed between baseline and Week 18. Success was classified as a response that ranged from disappearance to an increase <25% in tumor marker, tumor size, or symptom frequency. RESULTS. Sixty patients were randomized, and 46 patients completed the study. Both for tumor markers and for tumor size, Lan ATG was not inferior to Lan MP (55% and 59% of patients responded on tumor markers, respectively; 68% and 66% of patients responded on tumor size, respectively). There were too few symptomatic patients to compare carcinoid symptoms. Both treatments were tolerated well, and no safety concerns were identified. CONCLUSIONS. Lan ATG at a dose of 120 mg every 6 weeks was as effective for controlling NET as Lan MP at a dose of 60 mg every 3 weeks. Cancer 2006. © 2006 American Cancer Society.