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Intraoperative bile cytology of the dysplasia–carcinoma in situ sequence of gallbladder carcinoma
Author(s) -
Arora Vinod Kumar,
Kumar Sunil,
Singh Navjeevan,
Bhatia Arati
Publication year - 2005
Publication title -
cancer cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.21320
Subject(s) - medicine , gallbladder , carcinoma , cytology , dysplasia , histopathology , carcinoma in situ , cholecystectomy , pathology , cytopathology , papanicolaou stain , adenocarcinoma , metastatic carcinoma , atypical hyperplasia , hyperplasia , cholecystitis , gastroenterology , cancer , cervical cancer
BACKGROUND The preoperative diagnosis of noninvasive and early carcinoma of the gallbladder is considered to be both difficult and exceptional. In the current study, the authors conducted a cytologic analysis of bile in the intraoperative diagnosis of clinically unsuspected gallbladder carcinoma. METHODS Bile samples collected from 40 patients at the time of elective cholecystectomy were centrifuged. Smears prepared from the sediments were stained with May–Grünwald–Giemsa and Papanicolaou stains. Lesions were categorized as hyperplasia with or without metaplasia, dysplasia, carcinoma in situ, and invasive carcinoma. Cytologic diagnoses were compared with histopathology. RESULTS Two cases of carcinoma in situ and one case of invasive carcinoma diagnosed on bile cytology were confirmed by histopathology. No false‐positive diagnoses were made based on cytologic examination of aspirated bile. Cytohistologic concordance in cases of hyperplasia, dysplasia, and chronic cholecystitis varied from 56–60%. CONCLUSIONS Intraoperative bile cytology was found to be a reliable method for the detection of in situ and early invasive carcinoma of the gallbladder. Cancer (Cancer Cytopathol) 2005. © 2005 American Cancer Society.