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Overexpressed Id‐1 is associated with a high risk of hepatocellular carcinoma development in patients with cirrhosis without transcriptional repression of p16
Author(s) -
Matsuda Yasunobu,
Yamagiwa Satoshi,
Takamura Masaaki,
Honda Yutaka,
Ishimoto Yuiko,
Ichida Takafumi,
Aoyagi Yutaka
Publication year - 2005
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.21259
Subject(s) - hepatocellular carcinoma , cirrhosis , medicine , carcinogenesis , immunohistochemistry , cancer research , risk factor , carcinoma , cancer , gastroenterology , oncology , pathology
BACKGROUND Inhibitor of differentiation/DNA binding protein 1 (Id‐1) plays a pivotal role in the regulation of cell proliferation and carcinogenesis via inhibiting basic helix‐loop‐helix (HLH) transcription factors. Recently, Id‐1 was found to repress p16 in tumorous tissue specimens including hepatocellular carcinoma (HCC), but its relevance in precancerous liver tissues is unknown. METHODS Id‐1 expression in the liver tissue specimens of 112 patients with cirrhosis without HCC was studied by immunohistochemical analysis. Correlations were investigated between Id‐1 expression and clinicopathologic features, the status of p16, and the risk of HCC occurrence. RESULTS A high expression of Id‐1 was observed in 42 patients (38%). The level of Id‐1 expression was not associated with clinical standard parameters or the status of p16 in cirrhotic tissue specimens. The cumulative incidence of HCC development was significantly higher in a group of patients with high Id‐1 expression ( P = 0.0008). Multivariate analysis revealed that increased Id‐1 expression is an independent significant factor for the risk of HCC development in patients with cirrhosis (relative risk = 2.75, P = 0.003). CONCLUSIONS The results of the current study suggested that increased expression of Id‐1 may play an important role in the early step of hepatocarcinogenesis, and might serve as a useful marker for determining patients with cirrhosis with a high risk of HCC occurrence. Cancer 2005;104. © 2005 American Cancer Society.