Premium
Frequency of SOX Group B (SOX1, 2, 3) and ZIC2 antibodies in Turkish patients with small cell lung carcinoma and their correlation with clinical parameters
Author(s) -
Vural Burcak,
Chen LinChi,
Saip Pinar,
Chen YaoTseng,
Ustuner Zeki,
Gonen Mithat,
Simpson Andrew J. G.,
Old Lloyd J.,
Ozbek Ugur,
Gure Ali O.
Publication year - 2005
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.21088
Subject(s) - autoantibody , medicine , antibody , serology , immunology , small cell lung carcinoma , immune system , lung cancer , small cell carcinoma
BACKGROUND Expression of neuroectodermal markers is a key feature of small cell lung carcinoma (SCLC). Although immune responses against a number of these proteins have been associated with paraneoplastic neuronal disease (PND), most patients with SCLC have anti‐neuroectodermal antibodies in the absence of PND. Whether these immune responses affect the clinical outcome in SCLC is critical in understanding the potential value of these proteins as cancer vaccine targets as well as in the pathogenesis of PND. METHODS The authors investigated the frequency of immunoglobulin G autoantibodies against Sry‐like high‐mobility group box (SOX)1, 2, 3 and Zinc‐finger gene of the cerebellum (ZIC)2 proteins in stored serum samples from 90 patients utilizing the λ‐phage plaque assay. Data obtained from patient records were utilized to measure clinical correlates of seroreactivity. RESULTS Antibodies to SOX1 were present in 28% of patients and another 28% had anti‐ZIC2 antibodies, classifying these as some of the most frequent antibody responses observed in SCLC. None had autoimmune paraneoplastic disease. Antibody titers were frequently as high as ≥ 1:10 6 and were stable for ≤ 6 months after diagnosis. Seroreactivity against either SOX1 or ZIC2 correlated with younger age, lower lactate dehydrogenase levels, and better response to initial therapy. CONCLUSIONS The frequent and stable presence of SOX Group B and/or ZIC2 antibodies in SCLC, but not in healthy individuals examined, indicates they are serological markers of SCLC. However, the correlation between known clinical parameters of less aggressive disease and seroreactivity suggests that these antibodies are indicators of better prognosis in SCLC and warrants further studies to clarify the nature of the underlying immune responses. Cancer 2005. © 2005 American Cancer Society.