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Radiotherapy alone or combined with surgery for salivary gland carcinoma
Author(s) -
Mendenhall William M.,
Morris Christopher G.,
Amdur Robert J.,
Werning John W.,
Villaret Douglas B.
Publication year - 2005
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.21083
Subject(s) - medicine , multivariate analysis , radiation therapy , stage (stratigraphy) , adjuvant , distant metastasis , carcinoma , metastasis , surgery , t stage , salivary gland cancer , survival rate , gastroenterology , cancer , urology , oncology , paleontology , biology
BACKGROUND The authors analyzed the outcomes of patients treated with radiotherapy (RT) alone or combined with surgery for carcinoma of the salivary glands. METHODS Between October 1964 and June 2003, 224 previously untreated patients were treated with curative intent with RT alone ( n = 64) or combined with surgery ( n = 160) at the University of Florida College of Medicine (Gainesville, FL). The median follow‐up period was 5.0 years (range, 0.4–31.6 years). RESULTS The 10‐year local control rate was 75%. Multivariate analysis of local control revealed that T classification ( P < 0.0001) and treatment group ( P < 0.0001) impacted this end point. Patients treated with surgery and adjuvant RT had improved local control compared with patients treated with RT alone. The 10‐year locoregional control rate was 68%. Multivariate analysis of locoregional control revealed that overall stage ( P < 0.0001) and treatment group ( P = 0.0002) significantly influenced this end point. The 10‐year distant metastasis‐free survival rate was 68%. Multivariate analysis of distant metastasis‐free survival revealed that overall stage ( P < 0.0001) significantly influenced this end point. The 10‐year cause‐specific and overall survival rates were 57% and 44%, respectively. Multivariate analysis of cause‐specific survival revealed that overall stage ( P < 0.0001) significantly impacted this end point. Twenty‐three patients (10%) experienced severe complications. CONCLUSIONS A substantial proportion of patients with salivary gland carcinoma were cured with surgery combined with adjuvant RT. RT alone was used for patients with unresectable tumors and cured approximately 20% of those with advanced‐stage disease. The probability of cure was influenced by the extent of disease and treatment group. Cancer 2005. © 2005 American Cancer Society.