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Treatment of 72 newly diagnosed Waldenström macroglobulinemia cases with oral melphalan, cyclophosphamide, and prednisone
Author(s) -
Annibali Ombretta,
Petrucci Maria Teresa,
Martini Vincenza,
Tirindelli Maria Cristina,
Levi Anna,
Fossati Carolina,
Bianco Patrizia Del,
Mandelli Franco,
Foa Robin,
Avvisati Giuseppe
Publication year - 2005
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.20826
Subject(s) - medicine , macroglobulinemia , waldenstrom macroglobulinemia , prednisone , melphalan , regimen , nausea , neutropenia , cyclophosphamide , chlorambucil , gastroenterology , surgery , rituximab , multiple myeloma , chemotherapy , lymphoma
BACKGROUND Current treatment regimens for Waldenström macroglobulinemia (WM) are based on the use of oral alkylating agents. Recently, however, other more costly agents have been proposed for the treatment of WM. In the current study, the authors report on results obtained using oral melphalan, cyclophosphamide, and prednisone (MCP) to treat 72 patients with WM, and they compare these results (and the associated costs) with those observed using more aggressive protocols. METHODS Between July 1973 and April 2002, the authors documented overexpression of the immunoglobulin M paraprotein in 317 consecutive patients. Of these, 100 had newly diagnosed WM, and the 72 who were symptomatic were treated using the MCP protocol. Response rate, overall survival (OS), response duration, freedom from progression (FFP), event‐free survival (EFS) duration, toxicity, and cost per course in Euro and U.S. dollars were evaluated for patients receiving this regimen. RESULTS Seventy‐one of 72 patients (99%) were evaluable. Of these patients, 55 (77%) achieved a response; 7 others (10%) experienced disease stabilization, and the remaining 9 (13%) experienced disease progression. After a median follow‐up of 72 months (range, 3–195 months), the median durations of EFS, FFP, response, and OS were 47, 55, 64, and 66 months, respectively. No World Health Organization Grade III or IV toxicities were observed, and side effects were limited to transient nausea, emesis, and mild neutropenia. The cost per course of the MCP regimen was $16, similar to that of standard protocols involving chlorambucil and much less than that of more aggressive protocols (price range, $91–11091) proposed for the treatment of WM. CONCLUSIONS Like chlorambucil‐based protocols, the MCP regimen is a cost‐effective and safe option for the treatment of patients with WM. Furthermore, the results obtained do not appear to be inferior to those yielded by more expensive, aggressive, and toxic intravenous protocols. Cancer 2005. © 2004 American Cancer Society.