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Deep‐seated, well differentiated lipomatous tumors of the chest wall and extremities
Author(s) -
Bassett Mikelle D.,
Schuetze Scott M.,
Disteche Christine,
Norwood Thomas H.,
Swisshelm Karen,
Chen Xiaoqin,
Bruckner James,
Conrad Ernest U.,
Rubin Brian P.
Publication year - 2005
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.20779
Subject(s) - medicine , lipoma , histology , disease , intramuscular fat , pathology , radiology , biochemistry , chemistry
BACKGROUND Intramuscular lipomas and atypical lipomatous tumors (ALT) are common deep‐seated lipomatous tumors of the chest wall and extremities. Distinguishing between these two entities can be difficult based on histologic analysis alone. However, the cytogenetic profiles of ALT and intramuscular lipomas are distinct. Correct classification is important, because aggressive local disease recurrence occurs more frequently in patients with ALT than in patients with intramuscular lipoma. The authors examined their single institutional experience and correlated their classification with clinical features and outcome. METHODS In the current study, 106 patients with deep‐seated, well differentiated adipose tumors of the chest wall and extremities were classified as having ALT or intramuscular lipoma using a combined approach of histology and cytogenetics, if available. The classification was correlated with clinicopathologic features and follow‐up data. RESULTS Fifty‐five patients were classified as having intramuscular lipoma and 51 were classified as having ALT. Classification did not correlate with age and gender ( P = 0.28 and P = 0.96, respectively). Intramuscular lipomas were smaller than ALTs ( P < 0.0001), but there was significant overlap between the 2 groups. ALT occurred preferentially in the lower extremity ( P < 0.0009). Four percent of patients with intramuscular lipomas and 27% of patients with ALTs developed local disease recurrence ( P = 0.0006). Disease recurrence did not correlate with patient age at diagnosis, patient gender, tumor size, and tumor location ( P = 0.45, P = 0.26, P = 0.49, and P = 0.28, respectively). Within the subset of patients with ALTs, disease recurrence did not correlate with patient age at diagnosis, patient gender, or tumor location ( P = 0.38, P = 0.54, and P = 0.86, respectively). CONCLUSIONS Classification of deep‐seated, well differentiated lipomatous tumors of the extremities and chest wall using a combined approach of histology and cytogenetics correlated well with biologic behavior/disease recurrence. This combined approach is advocated to better stratify patients for treatment purposes and follow‐up. Cancer 2005. © 2004 American Cancer Society.