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The management of ductal carcinoma in situ in North America and Europe
Author(s) -
Ceilley Elizabeth,
Jagsi Reshma,
Goldberg Saveli,
Kachnic Lisa,
Powell Simon,
Taghian Alphonse
Publication year - 2004
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.20580
Subject(s) - medicine , ductal carcinoma , tamoxifen , breast cancer , family medicine , radiation therapy , oncology , gynecology , cancer
BACKGROUND The goal of the current study was to understand and document contemporary treatment approaches in the management of ductal carcinoma in situ (DCIS). METHODS An original questionnaire was designed to assess radiation oncologists' management of breast carcinoma, including 26 questions specifically addressing DCIS. A postal survey was conducted of members of the American and European Societies of Therapeutic Radiology and Oncology. The results of 702 responses from North America were compared with 435 responses from Europe, to determine treatment recommendations and variability by type of institution and geographic region. RESULTS There were strong correlations between the grade of DCIS and/or the margin status and the use of radiotherapy (RT; P < 0.0001). For Grade 3 DCIS, RT was recommended regardless of the margin status. Opinions were split in the treatment of low‐grade DCIS with 10‐mm margins. North American respondents were more likely to recommend RT for low‐grade DCIS than their European counterparts ( P < 0.0001). Within the United States, there were significant regional variations in physician recommendations for tamoxifen ( P < 0.001), but not in the tendency to recommend RT. North American academic physicians were less likely to recommend RT for favorable DCIS than nonacademic physicians ( P < 0.01). CONCLUSIONS There were marked differences in physician opinions regarding the management of DCIS, with significant international differences in patterns of care. The survey quantified and highlighted areas of agreement and controversy regarding the use of RT and tamoxifen in the management of DCIS. It provided support for large international trials to evaluate the optimal management of DCIS in the areas identified as most controversial. Cancer 2004. © 2004 American Cancer Society.