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The Importance of Prognostic Factors in Advanced Prostate Cancer
Author(s) -
Soloway Mark S.
Publication year - 1990
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.1990.66.s5.1017
Subject(s) - medicine , prostate cancer , oncology , testosterone (patch) , multivariate analysis , performance status , androgen , randomized controlled trial , cancer , prostate , overall survival , disease , hormone
Three factors were identified in a multivariate analysis of prognostic factors in men with metastatic prostate cancer as significantly associated with their progressionfree survival: 1) extent of disease on the bone scan, 2) pretreatment serum testosterone, and 3) performance status. Men with less than six bone metastases, a pretreatment testosterone < 300 ng/100 ml, and an excellent performance status will have a progression‐free survival much longer than a man with more extensive bone metastases, a low testosterone prior to androgen deprivation, and a poor performance status. This information should be used to ensure proper stratification in randomized trials. It may also be helpful in identifying the patient unlikely to be helped by our current treatment. Such patients should be considered for alternative approaches with the aim of improving survival.