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Increased risk of myelotoxicity in elderly patients with non‐Hodgkin lymphoma
Author(s) -
Balducci Lodovico,
Repetto Lazzaro
Publication year - 2003
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.11861
Subject(s) - medicine , vincristine , chemotherapy , prednisone , cyclophosphamide , neutropenia , lymphoma , chop , incidence (geometry) , oncology , non hodgkin's lymphoma , cancer , physics , optics
Neutropenia is the major dose‐limiting toxicity of myelosuppressive chemotherapy in patients with cancer. Because of the high incidence of neutropenic complications and death in the early cycles of chemotherapy and the potential for improved outcomes, prophylaxis with colony‐stimulating factor beginning in the first cycle should be routinely considered in elderly patients with non‐Hodgkin lymphoma who are treated with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) or CHOP‐like chemotherapy regimens.