Premium
The silence of the genes: Matching mismatch repair defects with tumors
Author(s) -
Boland C. Richard,
Goel Ajay
Publication year - 2003
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/cncr.11769
Subject(s) - medicine , epigenetics , gene silencing , gene , silence , dna mismatch repair , cancer , cancer research , bioinformatics , genetics , dna repair , biology , philosophy , aesthetics
Research over the past 20 years has shown that all cancers are diseases of genes. However, the genetic pathways to tumor development are complex and variable. Much of the work in the past decade has been to identify the pathways of development for tumors in individual organs, and to translate these findings into improved methods for the prevention and treatment of malignancies. In this issue of Cancer , Geisler et al. report the role of epigenetic silencing of the hMLH1 and hMSH2 genes in the genesis of ovarian carcinoma